Overview of the Analytes Applied in Genotypic HIV Drug Resistance Testing

The close monitoring of HIV drug resistance using genotypic HIV drug resistance testing (HIVDRT) has become essential for effective HIV/AIDS management at both individual and population levels. Over the years, a broad spectrum of analytes or specimens have been applied or attempted in HIVDRT; howeve...

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Bibliographic Details
Published inPathogens (Basel) Vol. 11; no. 7; p. 739
Main Authors Ji, Hezhao, Sandstrom, Paul
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 29.06.2022
MDPI
Subjects
Acquired immune deficiency syndrome
AIDS
analytes
Deoxyribonucleic acid
DNA
Drug resistance
HIV
Human immunodeficiency virus
Immune system
Mutation
Plasma
Population
Population levels
Review
specimens
Surveillance
testing
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Summary:The close monitoring of HIV drug resistance using genotypic HIV drug resistance testing (HIVDRT) has become essential for effective HIV/AIDS management at both individual and population levels. Over the years, a broad spectrum of analytes or specimens have been applied or attempted in HIVDRT; however, the suitability and performance of these analytes in HIVDRT and the clinical relevance of the results from them may vary significantly. This article provides a focused overview of the performance, strengths, and weaknesses of various analytes while used in HIVDRT, which may inform the optimal analytes selection in different application contexts.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens11070739