Effect of sılymarın on oxıdatıve stress and lıver hıstopathology ın experımental obstructıve jaundıce model

To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile duct ligation was performed...

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Published inActa cirurgica brasileira Vol. 31; no. 12; pp. 801 - 806
Main Authors Onalan, Ali Kemal, Tuncal, Salih, Kilicoglu, Sibel, Celepli, Salih, Durak, Esra, Kilicoglu, Bulent, Devrim, Erdinc, Barlas, Aziz Mutlu, Kismet, Kemal
Format Journal Article
LanguageEnglish
Published Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.12.2016
Subjects
Animals
Antioxidants - pharmacology
Bile Ducts
Female
Glutathione - blood
Jaundice
Jaundice, Obstructive - complications
Jaundice, Obstructive - pathology
Ligation
Liver
Liver - pathology
Male
Malondialdehyde - blood
Obstructive
Oxidative Stress
Oxidative Stress - drug effects
Protective Agents - pharmacology
Random Allocation
Rats
Rats, Wistar
Silymarin
Silymarin - pharmacology
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Summary:To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile duct ligation was performed in group 2. In group 3, bile duct ligation was performed and orogastic silymarin 300 mg/kg/day dose was given for seven days. At the end of seven days, rats were sacrificed. The blood and liver tissue samples were taken to be examined biochemically and histopathologically. The plasma and liver levels of malondialdehyde were significantly lower in silymarin group than in the bile duct ligated group. Although liver levels of GSH were significantly higher in silymarin group than in the bile duct ligated group, there was no significant difference between the plasma GSH levels of these groups. In silymarin group; the enlargement of hepatocytes, dilatation of canaliculi and the edema were regressed. Silymarin diminished the harmful effects of obstructive jaundice on liver.
ISSN:0102-8650
1678-2674
0102-8650
DOI:10.1590/S0102-865020160120000004