Codeine Precipitating Serotonin Syndrome in a Patient in Therapy with Antidepressant and Triptan

The serotonin syndrome is a serioius medical condition due due to an intensive stimulation of setonin receptors. It is a rare, but severe, consequence of interaction between serotomimetic agents. This is a report of a 70-year-old woman steadily in therapy with venlafaxine and rizatriptan for migrain...

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Published inClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology Vol. 15; no. 3; pp. 292 - 295
Main Authors Milano, Giulia, Natta, Werner Maria, Bello, Alfredo, Martelli, Antonietta, Mattioli, Francesca
Format Journal Article
LanguageEnglish
Published Korea (South) Korean College of Neuropsychopharmacology 01.08.2017
대한정신약물학회
Subjects
Case Report
정신과학
Prescription drug misuse
Drug-drug interactions
Migraine disorders
Serotonin syndrome
Major depressive disorder
Codeine
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Summary:The serotonin syndrome is a serioius medical condition due due to an intensive stimulation of setonin receptors. It is a rare, but severe, consequence of interaction between serotomimetic agents. This is a report of a 70-year-old woman steadily in therapy with venlafaxine and rizatriptan for migraine and major depressive syndrome. She was admitted to neurology unit for decreased light reflex with miotic pupils, global hyperreflexia, tremor, anxiety, ataxia and incoordination. The patient was diagnosed as a probable case of serotonin syndrome due to a pharmacological interaction between venlafaxine and rizatriptan trigged by opioid intake. In this paper, the development of syntomatology, the clinical examination and the possible pharmacokinetics explanation were carefully discussed and analysed.
Bibliography:https://doi.org/10.9758/cpn.2017.15.3.292
ISSN:1738-1088
2093-4327
DOI:10.9758/cpn.2017.15.3.292