The influence of 2 br-alpha-ergocryptine (CB-154) and apomorphine on induced prolactin secretion in the crab eating monkey (Macaca fascicularis)

The influence of apomorphine and 2 Br-alpha-ergocryptine (CB-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (Macaca fascicularis). Perphenazine administered iv at one mg/kg BW induced a rapid and marked increase in serum prolactin. Apomorphine at a co...

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Bibliographic Details
Published inEndocrine research communications Vol. 2; no. 1; p. 95
Main Authors Gala, R R, Jaques, Jr, S
Format Journal Article
LanguageEnglish
Published United States 1975
Subjects
Animals
Apomorphine - pharmacology
Bromocriptine - pharmacology
Castration
Ergolines - pharmacology
Female
Humans
Macaca fascicularis
Ovary - physiology
Perphenazine - pharmacology
Prolactin - blood
Prolactin - immunology
Radioimmunoassay
Thyrotropin-Releasing Hormone - pharmacology
Time Factors
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Summary:The influence of apomorphine and 2 Br-alpha-ergocryptine (CB-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (Macaca fascicularis). Perphenazine administered iv at one mg/kg BW induced a rapid and marked increase in serum prolactin. Apomorphine at a concentration of 4 mg/kg BW administered prior to perphenazine delayed the perphenazine-induced prolactin rise. The iv administration of CB-154 at either 200 or 2000 mu-g/kg BW completely blocked the perphenazine response. Apomorphine injected before TRH suppressed the induced prolactin increase to this releasing hormone while CB-154, even at the very high dose, only partially blocked the TRH-induced prolactin rise. Serotonin injected iv at the level of 10 mg/kg BW induced a rapid and marked increase in serum prolactin and both apomorphine and CB-154 were able to block this response.
ISSN:0093-6391
DOI:10.3109/07435807509053841