Insights from the Third Dimension: Cardiac Organoids Help Identify Regenerative Pathways

In this issue of Cell Stem Cell, Mills et al. (2019) use multidimensional functional screening to identify pro-proliferative compounds in cell-cycle-arrested human cardiac organoids. Using this model, the authors identify two hit compounds that restart cardiomyocyte proliferation by synergistically...

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Bibliographic Details
Published inCell stem cell Vol. 24; no. 6; pp. 833 - 834
Main Authors Caspi, Oren, Gepstein, Lior
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.06.2019
Subjects
Cell Cycle Checkpoints
Drug Evaluation, Preclinical
Heart
Humans
Mevalonic Acid
Organoids
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Summary:In this issue of Cell Stem Cell, Mills et al. (2019) use multidimensional functional screening to identify pro-proliferative compounds in cell-cycle-arrested human cardiac organoids. Using this model, the authors identify two hit compounds that restart cardiomyocyte proliferation by synergistically activating the mevalonate pathway and cell-cycle-related pathways. In this issue of Cell Stem Cell, Mills et al. (2019) use multidimensional functional screening to identify pro-proliferative compounds in cell-cycle-arrested human cardiac organoids. Using this model, the authors identify two hit compounds that restart cardiomyocyte proliferation by synergistically activating the mevalonate pathway and cell-cycle-related pathways.
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ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2019.05.012