Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs

• Published in: Drug metabolism and pharmacokinetics Vol. 60; p. 101046
• Main Authors: Kimura, Hiroshi, Nishikawa, Masaki, Kutsuzawa, Naokata, Tokito, Fumiya, Kobayashi, Takuma, Kurniawan, Dhimas Agung, Shioda, Hiroki, Cao, Wenxin, Shinha, Kenta, Nakamura, Hiroko, Doi, Kotaro, Sakai, Yasuyuki
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2025
• Subjects: Alternatives to animal testing; Animals; Drug development; Drug Development - methods; Drug Discovery - methods; Humans; Kidney - metabolism; Lab-On-A-Chip Devices; Liver - metabolism; Microphysiological Systems; Organ-on-a-chip; Organoid; Organoids - metabolism; Pharmacokinetics; Organoid; Organ-on-a-chip; Microphysiological systems; Drug development; Alternatives to animal testing

This study explored the evolving landscape of Microphysiological Systems (MPS), with a focus on organoids and organ-on-a-chip (OoC) technologies, which are promising alternatives to animal testing in drug discovery. MPS technology offers in vitro models with high physiological relevance, simulating...