Chimeric Antigen Receptor-Natural Killer Cells: A New Breakthrough in the Treatment of Solid Tumours

• Published in: Clinical oncology (Royal College of Radiologists (Great Britain)) Vol. 35; no. 3; pp. 153 - 162
• Main Authors: Pan, S., Wang, F., Jiang, J., Lin, Z., Chen, Z., Cao, T., Yang, L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2023
• Subjects: CAR-NK cells; Clinical trials; Hematologic Neoplasms; Humans; Immunotherapy, Adoptive - adverse effects; Killer Cells, Natural - metabolism; Neoplasms - therapy; NK cells; Preclinical studies; Receptors, Chimeric Antigen - metabolism; Solid tumour; Clinical trials; Preclinical studies; NK cells; CAR-NK cells; Solid tumour
• ISSN: 0936-6555; 1433-2981
• DOI: 10.1016/j.clon.2022.10.019

Natural killer (NK) cells can quickly and directly eradicate tumour cells without recognising tumour-specific antigens. NK cells also participate in immune surveillance, which arouses great interest in the development of novel cancer therapies. The chimeric antigen receptor (CAR) family is composed of receptor proteins that give immune cells extra capabilities to target specific antigen proteins or enhance their killing effects. CAR-T cell therapy has achieved initial success in haematological tumours, but is prone to adverse reactions, especially with cytokine release syndrome in clinical applications. Currently, CAR-NK cell therapy has been shown to successfully kill haematological tumour cells with allogeneic NK cells in clinical trials without adverse reactions, proving its potential to become an off-the-shelf product with broad clinical application prospects. Meanwhile, clinical trials of CAR-NK cells for solid tumours are currently underway. Here we will focus on the latest advances in CAR-NK cells, including preclinical and clinical trials in solid tumours, the advantages and challenges of CAR-NK cell therapy and new strategies to improve the safety and efficacy of CAR-NK cell therapy.