In phantom evaluation of targeting accuracy in MRI-based brain radiosurgery

• Published in: Physica medica Vol. 85; pp. 158 - 164
• Main Authors: Calusi, S., Arilli, C., Mussi, E., Puggelli, L., Farnesi, D., Casati, M., Compagnucci, A., Marrazzo, L., Talamonti, C., Zani, M., Pallotta, S.
• Format: Journal Article
• Language: English
• Published: Italy Elsevier Ltd 01.05.2021
• Subjects: 3D MR image distortion phantom; 3D printing; Brain phantom; MR/CT imaging quality control; Stereotactic radiosurgery accuracy; 3D MR image distortion phantom; MR/CT imaging quality control; Stereotactic radiosurgery accuracy; 3D printing; Brain phantom
• ISSN: 1120-1797; 1724-191X
• DOI: 10.1016/j.ejmp.2021.05.014

•High accuracy in stereotactic brain radiosurgery is crucial.•MR images distortions and image co-registration uncertainties affect treatment accuracy.•A phantom simulating a realistic anatomical situation allows for a realistic assessment of targeting accuracy.•A CT and MR compatible phantom allows testing of procedures involving different imaging modalities. To determine the targeting accuracy of brain radiosurgery when planning procedures employing different MRI and MRI + CT combinations are adopted. A new phantom, the BrainTool, has been designed and realized to test image co-registration and targeting accuracy in a realistic anatomical situation. The phantom was created with a 3D printer and materials that mimic realistic brain MRI and CT contrast using a model extracted from a synthetic MRI study of a human brain. Eight markers distributed within the BrainTool provide for assessment of the accuracy of image registrations while two cavities that host an ionization chamber are used to perform targeting accuracy measurements with an iterative cross-scan method. Two procedures employing 1.5 T MRI-only or a combination of MRI (taken with 1.5 T or 3 T scanners) and CT to carry out Gamma Knife treatments were investigated. As distortions can impact targeting accuracy, MR images were preliminary evaluated to assess image deformation extent using GammaTool phantom. MR images taken with both scanners showed average and maximum distortion of 0.3 mm and 1 mm respectively. The marker distances in co-registered images resulted below 0.5 mm for both MRI scans. The targeting mismatches obtained were 0.8 mm, 1.0 mm and 1.2 mm for MRI-only and MRI + CT (1,5T and 3 T), respectively. Procedures using a combination of MR and CT images provide targeting accuracies comparable to those of MRI-only procedures. The BrainTool proved to be a suitable tool for carrying out co-registration and targeting accuracy of Gamma Knife brain radiosurgery treatments.