Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems

Alginate is a biopolymer that has exceptional gelling properties, which allow easy gel formation under safe and mild conditions. Consequently, it is often used to encapsulate a variety of cargos, such as cells, enzymes, and lipids, and is typically employed as a model to study hydrogel-based encapsu...

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Published inParticuology Vol. 24; no. 1; pp. 44 - 60
Main Authors Leong, Jun-Yee, Lam, Weng-Hoong, Ho, Kiang-Wei, Voo, Wan-Ping, Lee, Micky Fu-Xiang, Lim, Hui-Peng, Lim, Swee-Lu, Tey, Beng-Ti, Poncelet, Denis, Chan, Eng-Seng
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.02.2016
Elsevier
Subjects
Alginate
Alginates
Chemical and Process Engineering
Design engineering
Dispersions
Encapsulation
Engineering Sciences
Gelation
Hydrogel
Hydrogels
Immobilization
Ionotropic gelation
Lipids
Production methods
产品设计
工业通用技术
粉末技术
颗粒学
Encapsulation
Immobilization
Alginate
Ionotropic gelation
Hydrogel
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Summary:Alginate is a biopolymer that has exceptional gelling properties, which allow easy gel formation under safe and mild conditions. Consequently, it is often used to encapsulate a variety of cargos, such as cells, enzymes, and lipids, and is typically employed as a model to study hydrogel-based encapsulation sys- tems. Since the first use of alginate in the encapsulation field in the 1970s, many methods have been developed to produce alginate hydrogel particles of different sizes, structures, and morphologies. This review provides an overview of the current progress in the fabrication of alginate hydrogels with vari- ous particle designs, including a discussion of dispersion techniques to pre-template alginate particles, gelation mechanisms, considerations in selecting suitable fabrication methods, and future directions.
Bibliography:Alginate is a biopolymer that has exceptional gelling properties, which allow easy gel formation under safe and mild conditions. Consequently, it is often used to encapsulate a variety of cargos, such as cells, enzymes, and lipids, and is typically employed as a model to study hydrogel-based encapsulation sys- tems. Since the first use of alginate in the encapsulation field in the 1970s, many methods have been developed to produce alginate hydrogel particles of different sizes, structures, and morphologies. This review provides an overview of the current progress in the fabrication of alginate hydrogels with vari- ous particle designs, including a discussion of dispersion techniques to pre-template alginate particles, gelation mechanisms, considerations in selecting suitable fabrication methods, and future directions.
11-5671/O3
Alginate lonotropic gelation Immobilization Encapsulation Hydrogel
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1674-2001
2210-4291
DOI:10.1016/j.partic.2015.09.004