Smuggling across the Border: How Arthropod-Borne Pathogens Evade and Exploit the Host Defense System of the Skin

The skin is a critical barrier between hosts and pathogens in arthropod-borne diseases. It harbors many resident cells and specific immune cells to arrest or limit infections by secreting inflammatory molecules or by directly killing pathogens. However, some pathogens are able to use specific skin c...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 134; no. 5; pp. 1211 - 1219
Main Authors Bernard, Quentin, Jaulhac, Benoit, Boulanger, Nathalie
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2014
Elsevier Limited
Subjects
Animals
Arthropod Vectors - microbiology
Arthropod Vectors - parasitology
Arthropod Vectors - virology
Arthropods - immunology
Humans
Immune System - microbiology
Immune System - parasitology
Immune System - virology
Infection - immunology
Infection - transmission
Skin - immunology
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Summary:The skin is a critical barrier between hosts and pathogens in arthropod-borne diseases. It harbors many resident cells and specific immune cells to arrest or limit infections by secreting inflammatory molecules or by directly killing pathogens. However, some pathogens are able to use specific skin cells and arthropod saliva for their initial development, to hide from the host immune system, and to establish persistent infection in the vertebrate host. A better understanding of the initial mechanisms taking place in the skin should allow the development of new strategies to fight these vector-borne pathogens that are spread worldwide and are of major medical importance.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0022-202X
1523-1747
DOI:10.1038/jid.2014.36