Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion

• Published in: Scandinavian journal of immunology Vol. 74; no. 2; pp. 186 - 194
• Main Authors: Beitnes, A.‐C. R., Ráki, M., Lundin, K. E. A., Jahnsen, J., Sollid, L. M., Jahnsen, F. L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011
• Subjects: Adult; Aged; Antigen-presenting cells; Antigens, CD - immunology; Antigens, Differentiation, Myelomonocytic - immunology; CD103 antigen; CD11c antigen; CD11c Antigen - immunology; CD163 antigen; CD1c antigen; Celiac disease; Celiac Disease - immunology; Celiac Disease - pathology; Cell activation; Cell Count; Dendritic cells; Dendritic Cells - immunology; Duodenum - immunology; Duodenum - pathology; Female; Histocompatibility antigen HLA; HLA-DQ Antigens - immunology; Humans; Inflammation; Integrin alpha Chains - immunology; Intestinal Mucosa - immunology; Intestinal Mucosa - pathology; Intestine; Lymphocytes T; Macrophages; Macrophages - immunology; Male; Middle Aged; Mucosa; Receptors, Cell Surface - immunology; Young Adult
• ISSN: 0300-9475; 1365-3083
• DOI: 10.1111/j.1365-3083.2011.02549.x

Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten‐specific T cells restricted by disease‐associated HLA‐DQ molecules. We have previously reported that mucosal CD11c+ dendritic cells (DCs) are responsible for activation of gluten‐reactive T cells within the coeliac lesion. In mice, intestinal CD11c+ DCs comprise several functionally distinct subsets. Here, we report that HLA‐DQ+ antigen‐presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163+CD11c− macrophages (74%), and CD11c+ cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103+ and CD1c+ DCs belonged to partly overlapping populations, whereas CD163+CD11c+ APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163+CD11c+ APCs, whereas the density of CD103+ and CD1c+ DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.