Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion

Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten‐specific T cells restricted by disease‐associated HLA‐DQ molecules. We have previously reported that mucosal CD11c+ dendritic cells (DCs) are responsible for activation of gluten‐reactive T cells within the coeli...

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Published inScandinavian journal of immunology Vol. 74; no. 2; pp. 186 - 194
Main Authors Beitnes, A.‐C. R., Ráki, M., Lundin, K. E. A., Jahnsen, J., Sollid, L. M., Jahnsen, F. L.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.08.2011
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Summary:Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten‐specific T cells restricted by disease‐associated HLA‐DQ molecules. We have previously reported that mucosal CD11c+ dendritic cells (DCs) are responsible for activation of gluten‐reactive T cells within the coeliac lesion. In mice, intestinal CD11c+ DCs comprise several functionally distinct subsets. Here, we report that HLA‐DQ+ antigen‐presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163+CD11c− macrophages (74%), and CD11c+ cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103+ and CD1c+ DCs belonged to partly overlapping populations, whereas CD163+CD11c+ APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163+CD11c+ APCs, whereas the density of CD103+ and CD1c+ DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.
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ISSN:0300-9475
1365-3083
DOI:10.1111/j.1365-3083.2011.02549.x