Predicting the prognoses of breast carcinoma patients with positron emission tomography using 2‐deoxy‐2‐fluoro[18F]‐D‐glucose

• Published in: Cancer Vol. 82; no. 11; pp. 2227 - 2234
• Main Authors: Oshida, Masaki, Uno, Kimiichi, Suzuki, Masato, Nagashima, Takeshi, Hashimoto, Hideyuki, Yagata, Hiroshi, Shishikura, Tanetomo, Imazeki, Keiko, Nakajima, Nobuyuki
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.06.1998; Wiley-Liss
• Subjects: 2‐deoxy‐2‐fluoro[18F]‐D‐glucose; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast; breast carcinoma; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - mortality; Female; Fluorodeoxyglucose F18; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Middle Aged; Multivariate Analysis; positron emission tomography; Prognosis; Tomography, Emission-Computed; Tumors; Radionuclide study; Human; Carcinoma; Prognosis; Malignant tumor; Glucose; Metabolism; Mammary gland diseases; Predictive value; Female; Mammary gland; Positron; Emission tomography
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/(SICI)1097-0142(19980601)82:11<2227::AID-CNCR18>3.0.CO;2-W

BACKGROUND Positron emission tomography (PET) with 2‐deoxy‐2‐fluoro[18F]‐D‐glucose (FDG) can provide quantitative information about tumor glucose metabolism. The prognostic value of this technique was evaluated for breast carcinoma patients. METHODS FDG PET was performed on 70 patients with primary breast carcinoma, and the differential absorption ratio (DAR) was calculated as an index of FDG uptake. Overall and relapse free survival curves were created by the Kaplan‐Meier method, and differences between the curves were analyzed with the log rank test. For multivariate analysis, the Cox proportional hazards regression model was used. RESULTS The mean DAR was 2.61 ± 1.61 standard deviation (range, 0.65‐9.39). According to the grade of DAR, patients were then classified into high DAR (≥3.0) and low DAR (<3.0) groups. The high DAR group had significantly worse prognoses for both overall and relapse free survival (P < 0.0005 and P < 0.0001, respectively). In multivariate analysis, DAR was an independent predictor of the relapse free survival of breast carcinoma patients (P = 0.0377). CONCLUSIONS DAR, as determined by FDG PET, may be useful as a prognostic indicator for patients with primary breast carcinoma. Cancer 1998;82:2227‐2234. © 1998 American Cancer Society. Positron emission tomography with 2‐deoxy‐2‐fluoro[18F]‐D‐glucose (FDG) was performed on 70 patients with primary breast carcinoma, and the differential absorption ratio calculated as an index of FDG uptake was found to be useful for predicting the prognoses of these patients.