Characterization of a human lymphoblastoid cell line permanently modified by simian foamy virus type 10

Simian Spumavirinae serotype, SFV10, of a Papio cynocephalus baboon, was used to infect a human lymphoblastoid cell line, LV2. Permanent growth and morphological alterations of infected cells occurred, even though no viral particles were detected. Evidence for the presence of viral genomes in the mo...

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Bibliographic Details
Published inJournal of medical primatology Vol. 16; no. 5; p. 277
Main Authors Rhodes-Feuillette, A, Mahouy, G, Lasneret, J, Flandrin, G, Peries, J
Format Journal Article
LanguageEnglish
Published Denmark 01.01.1987
Subjects
Animals
Cell Line, Transformed
Cell Transformation, Viral
Genes, Viral
Humans
Papio - microbiology
Retroviridae - pathogenicity
Spumavirus - genetics
Spumavirus - pathogenicity
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Summary:Simian Spumavirinae serotype, SFV10, of a Papio cynocephalus baboon, was used to infect a human lymphoblastoid cell line, LV2. Permanent growth and morphological alterations of infected cells occurred, even though no viral particles were detected. Evidence for the presence of viral genomes in the modified cell line is provided indirectly from immunological studies and induction experiments followed by coculture procedures. The permanently modified cell line obtained (LV2-FB10) is an interesting model for the investigation of the possible integration of foamy viruses into the host genomes.
ISSN:0047-2565
DOI:10.1111/j.1600-0684.1987.tb00336.x