The human squamous cervical carcinoma cell line, HOG-1, is responsive to steroid hormones

Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of cancer Vol. 52; no. 2; p. 247
Main Authors White, J O, Jones, R N, Croxtall, J D, Gleeson, R P, Krausz, T, Pervez, S, Jamil, A, Guida, L, Beesley, J E, Soutter, W P
Format Journal Article
LanguageEnglish
Published United States 09.09.1992
Subjects
Adult
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Cell Division - drug effects
Culture Media
Estradiol - pharmacology
Female
Humans
Medroxyprogesterone - analogs & derivatives
Medroxyprogesterone - pharmacology
Medroxyprogesterone Acetate
Tamoxifen - analogs & derivatives
Tamoxifen - pharmacology
Tumor Cells, Cultured
Uterine Cervical Neoplasms - chemistry
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - pathology
Online AccessGet more information

Cover

More Information
Summary:Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease.
ISSN:0020-7136
DOI:10.1002/ijc.2910520216