Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV

• Published in: Journal of medical primatology Vol. 21; no. 2-3; p. 99
• Main Authors: Marthas, M L, Miller, C J, Sutjipto, S, Higgins, J, Torten, J, Lohman, B L, Unger, R E, Ramos, R A, Kiyono, H, McGhee, J R
• Format: Journal Article
• Language: English
• Published: Denmark 01.02.1992
• Subjects: Administration, Intravaginal; Animals; Antibodies, Viral - analysis; Antibodies, Viral - blood; DNA, Viral - blood; Female; Leukocytes, Mononuclear - chemistry; Macaca mulatta; Polymerase Chain Reaction; Simian Acquired Immunodeficiency Syndrome - prevention & control; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - immunology; Vaccination - veterinary; Vaccines, Attenuated - administration & dosage; Vaccines, Inactivated - administration & dosage; Vagina - immunology; Viral Vaccines - administration & dosage; Viremia - veterinary
• ISSN: 0047-2565
• DOI: 10.1111/j.1600-0684.1992.tb00574.x

The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.