Release behavior of a polyanion‐crosslinked chitosan‐poly(N‐isopropylacrylamide) gel thermoresponsive material

• Published in: Journal of applied polymer science Vol. 135; no. 41
• Main Authors: Ueoka, Hiroki, Shimomura, Osamu, Ueda, Kayoko, Inada, Katsuhiro, Nomura, Ryoki
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 05.11.2018
• Subjects: Chitosan; Crosslinking; Cyanocobalamin; Drug delivery systems; Encapsulation; gels; Hydrogels; Isopropylacrylamide; Materials science; Polyelectrolytes; Polymers; polysaccharides; stimuli‐sensitive polymers; Swelling ratio
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.46732

ABSTRACT A novel type of temperature‐responsive hydrogel with sensitive release performance of an encapsulated compound was obtained. The temperature‐responsive hydrogel with a sensitive state change between 32 °C and 29 °C was prepared by physically crosslinking chitosan with a polyanion of tripolyphosphate and linear poly(N‐isopropylacrylamide) (PNIPAAm). Cyanocobalamin was used as a model drug and was encapsulated in the prepared hydrogel. The swelling ratio and release behavior of cyanocobalamin were evaluated. Hydrogels containing 3.0% chitosan and 3.0% PNIPAAm had the best swelling ratio and the maximum amount of released encapsulated cyanocobalamin. The amount of released cyanocobalamin was quantified at 25 °C and 40 °C to evaluate the release behavior. The encapsulated cyanocobalamin remained within the hydrogels at 25 °C and was rapidly released at 40 °C. After 1 min at 40 °C, the released amount was approximately 50% of the encapsulated cyanocobalamin. The temperature‐responsive hydrogels obtained have good performance for use in drug delivery systems. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46732.