Release behavior of a polyanion‐crosslinked chitosan‐poly(N‐isopropylacrylamide) gel thermoresponsive material
ABSTRACT A novel type of temperature‐responsive hydrogel with sensitive release performance of an encapsulated compound was obtained. The temperature‐responsive hydrogel with a sensitive state change between 32 °C and 29 °C was prepared by physically crosslinking chitosan with a polyanion of tripoly...
Saved in:
Published in | Journal of applied polymer science Vol. 135; no. 41 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc
05.11.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | ABSTRACT
A novel type of temperature‐responsive hydrogel with sensitive release performance of an encapsulated compound was obtained. The temperature‐responsive hydrogel with a sensitive state change between 32 °C and 29 °C was prepared by physically crosslinking chitosan with a polyanion of tripolyphosphate and linear poly(N‐isopropylacrylamide) (PNIPAAm). Cyanocobalamin was used as a model drug and was encapsulated in the prepared hydrogel. The swelling ratio and release behavior of cyanocobalamin were evaluated. Hydrogels containing 3.0% chitosan and 3.0% PNIPAAm had the best swelling ratio and the maximum amount of released encapsulated cyanocobalamin. The amount of released cyanocobalamin was quantified at 25 °C and 40 °C to evaluate the release behavior. The encapsulated cyanocobalamin remained within the hydrogels at 25 °C and was rapidly released at 40 °C. After 1 min at 40 °C, the released amount was approximately 50% of the encapsulated cyanocobalamin. The temperature‐responsive hydrogels obtained have good performance for use in drug delivery systems. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46732. |
---|---|
ISSN: | 0021-8995 1097-4628 |
DOI: | 10.1002/app.46732 |