Conjugated estrogens for the management of gastrointestinal bleeding secondary to uremia of acute renal failure

Bleeding commonly occurs secondary to the uremia of acute and chronic renal failure. Hemodialysis is indicated for the management of uremic bleeding, and administration of red blood cells and cryoprecipitate is also helpful. Desmopressin successfully reduces the bleeding tendency in patients with ch...

Full description

Saved in:
Bibliographic Details
Published inPharmacotherapy Vol. 18; no. 1; p. 210
Main Authors Heunisch, C, Resnick, D J, Vitello, J M, Martin, S J
Format Journal Article
LanguageEnglish
Published United States 01.01.1998
Subjects
Acute Kidney Injury - complications
Estrogens, Conjugated (USP) - therapeutic use
Fatal Outcome
Gastrointestinal Hemorrhage - drug therapy
Gastrointestinal Hemorrhage - etiology
Hemostatics - therapeutic use
Humans
Male
Middle Aged
Uremia - complications
Online AccessGet more information

Cover

More Information
Summary:Bleeding commonly occurs secondary to the uremia of acute and chronic renal failure. Hemodialysis is indicated for the management of uremic bleeding, and administration of red blood cells and cryoprecipitate is also helpful. Desmopressin successfully reduces the bleeding tendency in patients with chronic renal failure for short-term operations or procedures, but the frequency of tachyphylaxis is high and limits the drug's usefulness for major bleeds. Conjugated estrogens shorten bleeding times in uremia and may provide a more sustained hemostatic effect over desmopressin. A patient with acute renal failure and uncontrolled gastrointestinal bleeding was successfully treated with conjugated estrogens after failing desmopressin and octreotide therapy.
ISSN:0277-0008
DOI:10.1002/j.1875-9114.1998.tb03841.x