Relationship between structure and physical strength of silk fibroin nanofiber sheet depending on insolubilization treatment

ABSTRACT Materials such as expanded polytetrafluoroethylene and glutaraldehyde‐fixed bovine pericardium are currently used for cardiac tissue regeneration. However, patches made from these materials remain permanently without being absorbed by the body and must be replaced overtime because of degene...

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Bibliographic Details
Published inJournal of applied polymer science Vol. 134; no. 48
Main Authors Fukuda, Yasuhiro, Aytemiz, Derya, Higuchi, Akira, Ichida, Yuya, Asakura, Tetsuo, Kameda, Tsunenori, Nakazawa, Yasumoto
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 20.12.2017
Subjects
Biocompatibility
Biodegradability
Biodegradable materials
biomaterials
Degeneration
electrospinning
Glutaraldehyde
Materials science
mechanical properties
Methanol
Nanofibers
Pericardium
Physical properties
Polymers
Polytetrafluoroethylene
polyurethane
Polyurethane resins
Regeneration
Sheets
Silk fibroin
Tensile stress
Tissue engineering
Water vapor
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Summary:ABSTRACT Materials such as expanded polytetrafluoroethylene and glutaraldehyde‐fixed bovine pericardium are currently used for cardiac tissue regeneration. However, patches made from these materials remain permanently without being absorbed by the body and must be replaced overtime because of degeneration or lack of growth. To improve the long‐term outcomes for cardiac tissue regeneration, biocompatible and biodegradable materials must be used. In this study, we used two biocompatible polymers, silk fibroin (SF), which is biodegradable and segmented polyurethane, to prepare nonwoven sheets that were then insolubilized by water vapor or methanol treatment. The tensile stress increased significantly on adding segmented polyurethane to pure SF and the water vapor processed sheets showed higher extension on strain than the methanol‐processed sheets. The different insolubilization treatments also resulted in different SF structures. Our results show that it is possible to obtain the physical properties required for cardiac tissue repair patch by varying the insolubilization treatment. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45560.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.45560