Plasma HDL cholesterol and blood glucose in non-insulin-dependent diabetics related to liver lipids and microsomal enzyme activity

The major lipid predictors of coronary events, plasma high density lipoprotein cholesterol (HDL-C) and the HDL-C/total cholesterol (T-C) ratio, and blood glucose (BG) in 12 subjects with non-insulin-dependent diabetes mellitus were related to hepatic lipids, proteins and microsomal enzyme activity a...

Full description

Saved in:
Bibliographic Details
Published inActa medica Scandinavica Vol. 217; no. 5; p. 473
Main Authors Luoma, P V, Savolainen, M J, Sotaniemi, E A, Arranto, A J, Pelkonen, R O
Format Journal Article
LanguageEnglish
Published Sweden 01.01.1985
Subjects
Blood Glucose - metabolism
Blood Proteins - metabolism
Cholesterol - blood
Cholesterol, HDL - blood
Cytochrome P-450 Enzyme System - metabolism
Diabetes Mellitus, Type 2 - blood
Female
Humans
Lipid Metabolism
Liver - metabolism
Male
Microsomes, Liver - enzymology
Middle Aged
Online AccessGet more information

Cover

More Information
Summary:The major lipid predictors of coronary events, plasma high density lipoprotein cholesterol (HDL-C) and the HDL-C/total cholesterol (T-C) ratio, and blood glucose (BG) in 12 subjects with non-insulin-dependent diabetes mellitus were related to hepatic lipids, proteins and microsomal enzyme activity assessed by liver cytochrome P-450 (P-450). Non-insulin-dependent diabetics had low HDL-C/T-C ratio, liver phospholipid (PL) and P-450 and high serum and liver triglyceride (TG) concentrations. Plasma HDL-C was decreased, and BG high, especially in subjects with reduced PL and P-450. The HDL-C/T-C ratio was directly proportional to liver PL and P-450 and unrelated to hepatic TG. Increases in liver PL and microsomal enzyme activity may be favorably reflected both in cholesterol distribution and diabetic control.
ISSN:0001-6101
DOI:10.1111/j.0954-6820.1985.tb03250.x