Elevated levels of soluble ICAM-1 in sera from patients with bronchial asthma

We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during b...

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Bibliographic Details
Published inAllergy (Copenhagen) Vol. 48; no. 5; p. 370
Main Authors Hashimoto, S, Imai, K, Kobayashi, T, Amemiya, E, Takahashi, Y, Tomita, Y, Iwata, T, Suguro, H, Yamaguchi, M, Yachi, A
Format Journal Article
LanguageEnglish
Published Denmark 01.07.1993
Subjects
Adult
Asthma - blood
Cell Adhesion Molecules - blood
Humans
Hypersensitivity, Immediate - blood
Intercellular Adhesion Molecule-1
Middle Aged
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Summary:We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.
ISSN:0105-4538
DOI:10.1111/j.1398-9995.1993.tb02408.x