Gemcitabine pulmonary toxicity: CT features

The purpose of this case report is to describe the CT imaging features of pulmonary toxicity from gemcitabine, a relatively new chemotherapeutic agent, in three patients. CT features of gemcitabine pulmonary toxicity include ground glass opacity (n = 3), thickened septal lines (n = 3), and reticular...

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Bibliographic Details
Published inJournal of computer assisted tomography Vol. 24; no. 6; p. 977
Main Authors Boiselle, P M, Morrin, M M, Huberman, M S
Format Journal Article
LanguageEnglish
Published United States 01.11.2000
Subjects
Anti-Inflammatory Agents - therapeutic use
Antimetabolites, Antineoplastic - adverse effects
Carcinoma, Non-Small-Cell Lung - drug therapy
Deoxycytidine - adverse effects
Deoxycytidine - analogs & derivatives
Female
Follow-Up Studies
Glucocorticoids - therapeutic use
Humans
Lung - diagnostic imaging
Lung - drug effects
Lung Diseases, Interstitial - chemically induced
Lung Diseases, Interstitial - diagnostic imaging
Lung Neoplasms - drug therapy
Middle Aged
Ovarian Neoplasms - drug therapy
Prednisone - therapeutic use
Retrospective Studies
Tomography, X-Ray Computed
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Summary:The purpose of this case report is to describe the CT imaging features of pulmonary toxicity from gemcitabine, a relatively new chemotherapeutic agent, in three patients. CT features of gemcitabine pulmonary toxicity include ground glass opacity (n = 3), thickened septal lines (n = 3), and reticular opacities (n = 3). Distribution is diffuse and bilateral, and may be symmetric (n = 2) or asymmetric (n = 1). Clinical symptoms and imaging findings are potentially reversible with steroid therapy.
ISSN:0363-8715
DOI:10.1097/00004728-200011000-00027