Triterpenoid saponins with N-acetyl sugar from the bark of Albizia procera

• Published in: Phytochemistry (Oxford) Vol. 68; no. 9; pp. 1261 - 1266
• Main Authors: Melek, F.R., Miyase, Toshio, Ghaly, N.S., Nabil, Marian
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.05.2007; Elsevier
• Subjects: Acacic acid lactone; Albizia procera; Albizzia - chemistry; Biochemistry & Molecular Biology; Biological and medical sciences; Carbohydrates - chemistry; Cell Line, Tumor; Chemical constitution; Echinocystic acid; Fundamental and applied biological sciences. Psychology; General pharmacology; Humans; Leguminosae; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Bark - chemistry; Plant physiology and development; Plant Sciences; Saponins - chemistry; Saponins - isolation & purification; Saponins - toxicity; Science & Technology; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenoid saponin; Echinocystic acid; Leguminosae; Acacic acid lactone; Triterpenoid saponin; Albizia procera; MERYTA-LANCEOLATA; acacic acid lactone; triterpenoid saponin; echinocystic acid; Terpenoid; Molecular structure; Bark; Cytotoxicity; Lactone; Biological activity; Medicinal plant; Saponin; Cell line; Dicotyledones; Angiospermae; Triterpene; Isolation; Spermatophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2007.02.023

Four triterpenoid saponins were isolated from the bark of Albizia procera. Their structures were elucidated by 1D and 2D NMR experiments, FABMS as well as chemical means. The cytotoxic activities of the isolates were evaluated. Three ( 1, 2, 4) and one known ( 3) triterpenoid saponins were isolated from the bark of Albizia procera. The saponins were characterized as 3- O-[β- d-xylopyranosyl-(1 → 2)-α- l-arabinopyranosyl-(1 → 6)-2-acetamido-2-deoxy-β- d-glucopyranosyl] echinocystic acid ( 1), 3- O-[α- l-arabinopyranosyl-(1 → 2)-β- d-fucopyranosyl-(1 → 6)-2-acetamido-2-deoxy-β- d-glucopyranosyl] echinocystic acid ( 2) and 3- O-[β- d-xylopyranosyl-(1 → 2)-α- l-arabinopyranosyl-(1 → 6)-2-acetamido-2-deoxy-β- d-glucopyranosyl] acacic acid lactone ( 4). Their structures were elucidated by 1D and 2D NMR experiments, FABMS as well as chemical means. Saponins 1 and 3 exhibited cytotoxicity against HEPG2 cell line with IC 50 9.13 μg/ml and 10 μg/ml, respectively.