DNA-based asymmetric catalysis
The unique chiral structure of DNA has been a source of inspiration for the development of a new class of bio-inspired catalysts. The novel concept of DNA-based asymmetric catalysis, which was introduced only five years ago, has been applied successfully in a variety of catalytic enantioselective re...
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| Published in | Chemical Society reviews Vol. 39; no. 6; pp. 283 - 292 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.06.2010
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The unique chiral structure of DNA has been a source of inspiration for the development of a new class of bio-inspired catalysts. The novel concept of DNA-based asymmetric catalysis, which was introduced only five years ago, has been applied successfully in a variety of catalytic enantioselective reactions. In this
tutorial review
, the ideas behind this novel concept will be introduced, an overview of the catalytic chemistry available to date will be given and the role of DNA in catalysis will be discussed. Finally, an overview of new developments of potential interest for DNA-based asymmetric catalysis will be provided.
The unique chiral structure of DNA is a source of inspiration for the development of novel concepts in bio-inspired asymmetric catalysis. |
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| Bibliography: | Arnold J. Boersma was born in 1979 in Bergum, The Netherlands. He obtained his MSc in organic chemistry, in 2005, at the University of Groningen. He received his PhD degree under the guidance of Prof. Ben. L. Feringa and Dr Gerard Roelfes at the University of Groningen, in 2009 on the topic of DNA-based asymmetric catalysis. He is currently undertaking a postdoctoral research fellowship in the group of Prof. Hagan Bayley at the University of Oxford, England. Rik P. Megens was born in Harderwijk, The Netherlands, in 1984. In 2007 he obtained his MSc in chemistry from the University of Groningen with specialization in organic chemistry. Currently he is working as a PhD student in the group of Dr G. Roelfes on DNA-based catalysis. Ben L. Feringa obtained his PhD degree in 1978 at the University of Groningen under the guidance of Professor Hans Wynberg. After working as a research scientist at Shell, he was appointed Full Professor at the University of Groningen in 1988 and named the distinguished Jacobus H. van't Hoff Professor of Molecular Sciences in 2004. He was elected foreign honorary member of the American Academy of Arts and Sciences, and member of the Royal Netherlands Academy of Sciences (KNAW). In 2008 he was appointed as Academy Professor of the KNAW. His research interests include stereochemistry, organic synthesis, asymmetric catalysis, molecular switches and motors, self-assembly and nanosystems. Gerard Roelfes obtained his MSc from the University of Groningen, where he also completed his PhD in 2000, under the guidance of Prof. Ben L. Feringa, in a collaborative project with Prof. L. Que, Jr, University of Minnesota. He then went for a post-doc with Prof. Donald Hilvert at the ETH-Zürich. In 2003 he returned to the University of Groningen as a junior project leader. Currently, he is Assistant Professor of Biomolecular Chemistry. The central theme in his research is developing new bio-inspired concepts in catalysis. The main research topics in the Roelfes group are DNA-based asymmetric catalysis, modular assembly of novel DNA-based (catalytic) systems and semi-synthetic proteins, with a particular focus on artificial metalloenzymes. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/b811349c |