MR Imaging-based Multimodal Autoidentification of Perivascular Spaces (mMAPS): Automated Morphologic Segmentation of Enlarged Perivascular Spaces at Clinical Field Strength

• Published in: Radiology Vol. 286; no. 2; pp. 632 - 642
• Main Authors: Boespflug, Erin L, Schwartz, Daniel L, Lahna, David, Pollock, Jeffrey, Iliff, Jeffrey J, Kaye, Jeffrey A, Rooney, William, Silbert, Lisa C
• Format: Journal Article
• Language: English
• Published: United States Radiological Society of North America 01.02.2018
• Subjects: Aged; Aged, 80 and over; Cerebrovascular Circulation - physiology; Female; Humans; Magnetic Resonance Imaging - methods; Male; Multimodal Imaging - methods; Neuroimaging - methods; Original Research; Retrospective Studies; Signal-To-Noise Ratio; White Matter - anatomy & histology; White Matter - blood supply
• ISSN: 0033-8419; 1527-1315
• DOI: 10.1148/radiol.2017170205

Purpose To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0-T) magnetic resonance (MR) imaging data. Materials and Methods In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2-weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established single-section guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P < .001; r = 0.69, P < .001; and r = 0.54, P < .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P < .01) and total ePVS number (r = 0.76, P < .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual whole-brain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features. RSNA, 2017 Online supplemental material is available for this article.