Evaluation of the Symptomatic Treatment of Residual Neurological Symptoms in Wilson Disease

The intention of this analysis was to identify patients with treated Wilson disease (WD) and residual neurological symptoms in order to determine whether or not they were undergoing any treatment in addition to the common decoppering medication. Moreover, the effects of any symptomatic medication we...

Full description

Saved in:
Bibliographic Details
Published inEuropean neurology Vol. 64; no. 2; pp. 83 - 87
Main Authors Hölscher, Sara, Leinweber, Barbara, Hefter, Harald, Reuner, Ulrike, Günther, Peter, Weiss, Karl Heinz, Oertel, Wolfgang H., Möller, Jens Carsten
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.08.2010
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:The intention of this analysis was to identify patients with treated Wilson disease (WD) and residual neurological symptoms in order to determine whether or not they were undergoing any treatment in addition to the common decoppering medication. Moreover, the effects of any symptomatic medication were analyzed. Two samples of WD patients were investigated either by a mailed questionnaire survey (n = 135) or by a retrospective analysis (n = 75). A considerable proportion of patients still suffered from neurological symptoms (n = 106, 50.5%), of whom a relatively small proportion was treated symptomatically (n = 33, 31.1%). The documented effects varied substantially, with anticholinergics and botulinum toxin (against dystonia) and primidone (against tremor) apparently being the most promising compounds. Further studies are required to analyze the symptomatic treatment of WD patients with residual neurological symptoms in more detail.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ISSN:0014-3022
1421-9913
DOI:10.1159/000316066