The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin a...

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Bibliographic Details
Published inPharmaceuticals (Basel, Switzerland) Vol. 6; no. 4; pp. 500 - 509
Main Authors Deng, Huayun, Fang, Ye
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.04.2013
MDPI
Subjects
benserazide
catechol
GPR35
pyrogallol
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Summary:Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
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ISSN:1424-8247
1424-8247
DOI:10.3390/ph6040500