Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 48; pp. 13566 - 13573
• Main Authors: Lin, Wei-Chen, Wong, Jau-Min, Tung, Chien-Chih, Lin, Ching-Pin, Chou, Jen-Wei, Wang, Horng-Yuan, Shieh, Ming-Jium, Chang, Chin-Hao, Liu, Heng-Hsiu, Wei, Shu-Chen
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.12.2015
• Subjects: Adolescent; Adult; Aged; Asian Continental Ancestry Group; Biomarkers - analysis; C-Reactive Protein - analysis; Colitis, Ulcerative - ethnology; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Colitis, Ulcerative - therapy; Colon - chemistry; Colon - drug effects; Colon - pathology; Colonoscopy; Crohn Disease - ethnology; Crohn Disease - metabolism; Crohn Disease - pathology; Crohn Disease - therapy; Feces - chemistry; Female; Humans; Leukocyte L1 Antigen Complex - analysis; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Prospective Study; Remission Induction; Severity of Illness Index; Taiwan; Treatment Outcome; Young Adult; Fecal calprotectin; Inflammatory bowel disease; Endoscopic score; Crohn’s disease; Ulcerative colitis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v21.i48.13566

To evaluate the correlation between fecal calprotectin (fC), C-reactive protein (CRP), and endoscopic disease score in Asian inflammatory bowel disease (IBD) patients. Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity (CDEIS) and ulcerative colitis endoscopic index of severity (UCEIS) were used for endoscopic lesion scoring. A total of 88 IBD patients [36 patients with Crohn's disease (CD) and 52 with ulcerative colitis (UC)] were enrolled. For CD patients, fC correlated with CDEIS (r = 0.465, P = 0.005) and CRP (r = 0.528, P = 0.001). fC levels in UC patients correlated with UCEIS (r = 0.696, P < 0.0001) and CRP (r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission (CDEIS < 6) with 50% sensitivity and 100% specificity (AUC: 0.74) in CD patients when using 918 μg/g as the cut-off. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission (UCEIS < 3) with 88% sensitivity and 75% specificity (AUC: 0.87). fC correlated with both CDEIS and UCEIS. fC could be used as a predictor of endoscopic remission for Asian IBD patients.