Four new chromone derivatives from the Arctic fungus Phoma muscivora CPCC 401424 and their antiviral activities
The crude extract of the Arctic fungus Phoma muscivora CPCC 401424 displayed anti-influenza A virus activities which led us to investigated their secondary metabolites. Four new chromone derivatives, phomarcticones A–D ( 1 – 4 ) and five known chromone analogs ( 5 – 9 ) have been isolated from Arcti...
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Published in | Journal of antibiotics Vol. 76; no. 2; pp. 88 - 92 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.02.2023
Springer Nature Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | The crude extract of the Arctic fungus
Phoma muscivora
CPCC 401424 displayed anti-influenza A virus activities which led us to investigated their secondary metabolites. Four new chromone derivatives, phomarcticones A–D (
1
–
4
) and five known chromone analogs (
5
–
9
) have been isolated from Arctic fungus
Phoma muscivora
CPCC 401424. Compounds
3
and
4
possess rare sulfoxide groups in chromone derivatives. Their structures and absolute configurations were elucidated by extensive analysis of spectroscopic data, electronic circular dichroism, and comparison with reported data. Compounds
3
,
7
, and
9
showed significant anti-influenza A virus activities with the IC
50
values of 24.4, 4.2, and 2.7 μM, respectively. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.1038/s41429-022-00588-6 |