Four new chromone derivatives from the Arctic fungus Phoma muscivora CPCC 401424 and their antiviral activities

• Published in: Journal of antibiotics Vol. 76; no. 2; pp. 88 - 92
• Main Authors: Tang, Yan, Gu, Guowei, Wang, Jing, Guo, Zhe, Zhang, Tao, Cen, Shan, Dai, Shengjun, Yu, Liyan, Zhang, Dewu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2023; Springer Nature; Nature Publishing Group
• Subjects: 631/1647/2230; 631/92/349; Antibiotics; Antiviral Agents - chemistry; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Chromatography; Chromones - chemistry; Chromones - pharmacology; Circular Dichroism; Cytotoxicity; Dichroism; Fungi; Immunology; Influenza; Influenza A; Investigations; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Metabolites; Microbiology; Molecular Structure; Natural products; Organic Chemistry; Pharmacology & Pharmacy; Phoma; Science & Technology; Secondary metabolites; Solvents; Viruses; ENDOPHYTIC FUNGUS
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/s41429-022-00588-6

The crude extract of the Arctic fungus Phoma muscivora CPCC 401424 displayed anti-influenza A virus activities which led us to investigated their secondary metabolites. Four new chromone derivatives, phomarcticones A–D ( 1 – 4 ) and five known chromone analogs ( 5 – 9 ) have been isolated from Arctic fungus Phoma muscivora CPCC 401424. Compounds 3 and 4 possess rare sulfoxide groups in chromone derivatives. Their structures and absolute configurations were elucidated by extensive analysis of spectroscopic data, electronic circular dichroism, and comparison with reported data. Compounds 3 , 7 , and 9 showed significant anti-influenza A virus activities with the IC 50 values of 24.4, 4.2, and 2.7 μM, respectively.