A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl

• Published in: Natural product research Vol. 30; no. 10; pp. 1109 - 1115
• Main Authors: Tajuddeen, Nasir, Sallau, Muhammad S., Musa, Aliyu M., Yahaya, Sani M., Habila, James D., Ismail, Abdullahi Musa
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.05.2016
• Subjects: 2D NMR; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Bacillus cereus; Burseraceae; Candida albicans; Candida albicans - drug effects; Commiphora - chemistry; Commiphora pedunculata; Escherichia coli; Escherichia coli - drug effects; flavonoids; Flavonoids - isolation & purification; Flavonoids - pharmacology; Microbial Sensitivity Tests; Molecular Structure; Pedunculata; Plant Bark - chemistry; Plant Extracts - chemistry; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Shigella; Staphylococcus aureus; Staphylococcus aureus - drug effects; VRE; Commiphora pedunculata; VRE; Burseraceae; flavonoids; 2D NMR
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2015.1041138

A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl-2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epicatechin was isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against 9 out of 12 tested microorganisms including a resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli, Staphylococcus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The minimum inhibitory concentration was as low as 6.25 μg/mL against Shigella dysentriae, Bacillus cereus and S. aureus while the minimum bactericidal concentration was as low as 50 μg/mL against Pseudomonas aeruginosa, VRE and C. albicans. This is the first report of the isolation of the compound.