Trypanosoma cruzi:T Cell Subpopulations in the Peyer's Patches of BALB/c Infected Mice

• Published in: Experimental parasitology Vol. 87; no. 1; pp. 58 - 64
• Main Authors: Antunez, Maria Inés, Feinstein, Ricardo E., Cardoni, Rita L., Grönvik, Kjell-Olov
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.09.1997; Elsevier
• Subjects: Acute Disease; AIDS/HIV; Animals; BALB/c mice; Biological and medical sciences; CD4-CD8 Ratio; Chagas Disease - immunology; Chagas Disease - pathology; Correlation coefficient (r2); Experimental protozoal diseases and models; Flow Cytometry; Infectious diseases; Male; Medical sciences; Mice; Mice, Inbred BALB C; Parasitemia - immunology; Parasitemia - pathology; Parasitic diseases; Peyer's patches; Peyer's Patches - immunology; Peyer's Patches - pathology; Protozoal diseases; Protozoan; T cells; T-Lymphocyte Subsets - pathology; thymus; Thymus Gland - immunology; Thymus Gland - pathology; Trypanosoma cruzi; Peyer's patches; thymus; pi, postinfection; SCID, severe combined immune deficiency; Ig, immunoglobulin; SC, subcutaneous; mAb, monoclonal antibody; FITC, fluorescein isothiocyanate; Protozoan; T cells; Trypanosoma cruzi; BALB/c mice; PE, phycoerythrin; FACS, fluorescence activated cell sorter; PBS, phosphate-buffered saline; LD50, lethal dose fifty; Correlation coefficient (r2); ip, intraperitoneally; FCS, fetal calf serum; TCR, T cell receptor; Kinetoplastida; Protozoa; Protozoal disease; Peyer patch; Thymus gland; Rodentia; Parasite; Parasitosis; Infection; Vertebrata; Experimental disease; Mammalia; Depletion; Mouse; Pathogenic; T-Lymphocyte; Trypanosomiasis
• ISSN: 0014-4894; 1090-2449
• DOI: 10.1006/expr.1997.4171

The changes in the T cell subsets of the Peyer's patches and the thymus were analyzed in BALB/c mice infected withTrypanosoma cruzi,Tulahuén strain. During the acute stage of the infection both lymphoid organs drastically reduced their cellularity. This was mainly due to the decrease in the immature CD4+CD8+T cell population in the thymus and in both T and B cells in the Peyer's patches. In the acute infection, few Peyer's patches were found and the histological studies revealed a depletion of the thymic-dependent areas, paralleling the decreased number of cells expressing CD4 and αβ T cell receptor. After 14 weeks, in the late stage of the infection, the cellularity and the levels of the T cell subsets studied returned to values similar to those of noninfected mice.