The Relationship Between Vitamin D Levels and Receptor Activator of Nuclear Factor Ligand in Hashimoto’s Thyroiditis

• Published in: Haseki tıp bülteni Vol. 55; no. 4; pp. 261 - 268
• Main Authors: Yavuzer, Hakan, Işık, Selver, Cengiz, Mahir, Bolayırlı, İbrahim Murat, Döventaş, Alper, Erdinçler, Deniz Suna
• Format: Journal Article
• Language: English
• Published: Istanbul Haseki Eğitim ve Araştırma Hastanesi 01.12.2017; Galenos Publishing House; Galenos Yayinevi
• Subjects: Bans; Bone marrow; Cytokines; Diabetes; Growth factors; Hashimoto’s thyroiditis; Hormones; Hypothyroidism; Immune system; Iodine; Ligands; Lymphocytes; Metabolism; Multiple sclerosis; Osteoporosis; receptor activator of nuclear factor ligand; Sağlık Hizmetleri; Studies; Thyroid gland; Tıp; Tumor necrosis factor-TNF; Vitamin D; Vitamin deficiency; İstanbul; Türkiye; Hashimoto’s thyroiditis; Hashimoto tiroiditi; vitamin D; eseptör aktivatör nükleer kappa-B ligandı; eceptor activator of nuclear factor ligand
• ISSN: 1302-0072; 2147-2688
• DOI: 10.4274/haseki.21931

Aim: In order to analyze the relationship of Hashimoto’s thyroiditis with vitamin D and osteoclastogenic markers, we investigated vitamin D, osteoprotegerin (OPG) and receptor activator of nuclear factor ligand (RANKL) levels in patients over 60 years with and without Hashimoto’s thyroiditis. Methods: Eighty three female patients (49 with and 34 without Hashimoto’s thyroiditis), who attended the endocrinology and geriatrics departments between May 2013 and October 2013 were included in the study. Results: There was no statistically significant difference in the levels of vitamin D, OPG and RANKL between the groups. Vitamin D was significantly correlated with OPG and RANKL in patients with Hashimoto’s thyroiditis. In addition, a significant relationship was found between OPG and RANKL levels. Of the patients with Hashimoto’s thyroiditis, 33 were autoantibody-positive and 16 were negative. Vitamin D, OPG and RANKL levels were significantly lower in antibody-positive patients than in negative subjects. Conclucion: There were no differences in vitamin D, OPG and RANKL levels between patients with and without Hashimoto’s thyroidits. Autoantibody-positive Hashimoto’s thyroiditis group had statistically significantly lower vitamin D, OPG and RANKL levels. This reverse correlation suggests that autoantibodies may have an effect on osteoclastogenesis.