Plasma sRAGE Is Independently Associated With Urinary Albumin Excretion in Type 2 Diabetes

• Published in: Diabetes care Vol. 29; no. 5; pp. 1111 - 1113
• Main Authors: Humpert, Per M, Kopf, Stefan, Djuric, Zdenka, Wendt, Thoralf, Morcos, Michael, Nawroth, Peter P, Bierhaus, Angelika
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2006
• Subjects: Albuminuria; Biological and medical sciences; Biomarkers - blood; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - blood; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Humans; Medical sciences; Nephrology. Urinary tract diseases; Plasma; Proteins; Receptor for Advanced Glycation End Products; Receptors, Immunologic - blood; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urine; Endocrinopathy; Type 2 diabetes; Human; Urine; Excretion; Urinary system disease; Albumin; Metabolic diseases; Receptor for Advanced Glycosylated End products; Blood plasma; Proteinuria
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc05-2478

The receptor for advanced glycation end products (RAGE) has been shown to be involved in the pathogenesis of late diabetes complications. However, little is known about the physiologic function of endogenous sRAGE, a splice variant of the full-length receptor found in plasma. It was recently reported that plasma sRAGE levels are diminished in type 1 and type 2 diabetes and correlate inversely with intima-media thickness suggesting a protective role of high sRAGE levels in the development of late vascular complications. Humpert et al aim to decipher an association of plasma sRAGE with albuminuria as a marker of micro-vascular damage in 90 patients with type 2 diabetes and regular glomerular filtration rate.