The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion

To determine whether vitamin K administration affects urinary calcium excretion in postmenopausal women. Before- and after-trials with a 2-week treatment period. Healthy postmenopausal women (55 to 75 years old) were recruited from the convents in and around Maastricht. Controls (25 to 40 years old)...

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Bibliographic Details
Published inAnnals of internal medicine Vol. 111; no. 12; p. 1001
Main Authors Knapen, M H, Hamulyák, K, Vermeer, C
Format Journal Article
LanguageEnglish
Published United States 15.12.1989
Subjects
Adult
Aged
Calcium - urine
Data Interpretation, Statistical
Durapatite
Female
Humans
Hydroxyapatites
Hydroxyproline - urine
Menopause - blood
Menopause - urine
Middle Aged
Osteocalcin - blood
Osteocalcin - drug effects
Protein Binding
Radioimmunoassay
Vitamin K - pharmacology
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Summary:To determine whether vitamin K administration affects urinary calcium excretion in postmenopausal women. Before- and after-trials with a 2-week treatment period. Healthy postmenopausal women (55 to 75 years old) were recruited from the convents in and around Maastricht. Controls (25 to 40 years old) were healthy premenopausal volunteers. Daily administration of 1 mg of vitamin K for 2 weeks. Serum immunoreactive osteocalcin: hydroxylapatite binding (HAB) capacity of serum immunoreactive osteocalcin; excretion of calcium, hydroxyproline, and creatinine in the urine during the last 2 h of a 16-h fasting period. In premenopausal women, no effect of vitamin K administration was seen. In the postmenopausal group, vitamin K induced increased serum immunoreactive osteocalcin concentration; normalization of the HAB capacity of serum immunoreactive osteocalcin (this marker was less than 50% that of the controls in the pretreatment samples); a decrease in urinary calcium excretion, notably in the "fast losers" of calcium; and a parallel decrease in urinary hydroxyproline excretion in the fast losers of calcium. The serum immunoreactive osteocalcin level may vary with vitamin K status. This variance should be taken into consideration if osteocalcin is used as a marker for osteoblast activity. Vitamin K is one factor that may play a role in the loss of bone mass in postmenopausal osteoporosis.
ISSN:0003-4819
DOI:10.7326/0003-4819-111-12-1001