Prospects for the therapeutic development of umbilical cord blood-derived mesenchymal stem cells

Umbilical cord blood (UCB) is a primitive and abundant source of mesenchymal stem cells (MSCs). UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders. Despite the high latent self-renewal and differentiation capacity of these cells, the safety, effi...

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Published inWorld journal of stem cells Vol. 12; no. 12; pp. 1511 - 1528
Main Authors Um, Soyoun, Ha, Jueun, Choi, Soo Jin, Oh, Wonil, Jin, Hye Jin
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 26.12.2020
Subjects
Review
Mesenchymal stem cell
Therapeutic cell manufacturing processing
Stem cell therapy
Umbilical cord blood
Immunomodulation
Regenerative medicine
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Summary:Umbilical cord blood (UCB) is a primitive and abundant source of mesenchymal stem cells (MSCs). UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders. Despite the high latent self-renewal and differentiation capacity of these cells, the safety, efficacy, and yield of MSCs expanded for clinical applications remains a concern. However, immunomodulatory effects have emerged in various disease models, exhibiting specific mechanisms of action, such as cell migration and homing, angiogenesis, anti-apoptosis, proliferation, anti-cancer, anti-fibrosis, anti-inflammation and tissue regeneration. Herein, we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies, and discuss the concerns regarding the safety and mass production issues in future applications.
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Corresponding author: Hye Jin Jin, PhD, Director, Senior Researcher, Biomedical Research Institute, MEDIPOST Co., Ltd., 21, Daewangpangyo-ro 644-gil, Bundang-gu, Seongnam 13494, South Korea. genny77@medi-post.co.kr
Author contributions: Um S and Jin HJ wrote the manuscript; Ha J and Choi SJ and Oh W collected the data and provided the resources. All authors have read and approve the final manuscript.
ISSN:1948-0210
1948-0210
DOI:10.4252/wjsc.v12.i12.1511