Multidrug-resistant Pseudomonas aeruginosa infections pose growing threat to health care–associated infection control in the hospitals of Southern China: A case-control surveillance study

• Published in: American journal of infection control Vol. 42; no. 12; pp. 1308 - 1311
• Main Authors: Peng, Yang, MSc, Bi, Jiaqi, MSc, Shi, Jing, BMed, Li, Ying, BMed, Ye, Xiaohua, PhD, Chen, Xiaofeng, MSc, Yao, Zhenjiang, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2014; Elsevier; Mosby-Year Book, Inc
• Subjects: Anti-Bacterial Agents - therapeutic use; Biological and medical sciences; Carbapenems - therapeutic use; Case-Control Studies; Case-control surveillance; China - epidemiology; Clinical outcomes; Communicable Diseases - epidemiology; Communicable Diseases - microbiology; Cross Infection - epidemiology; Cross Infection - microbiology; Disease control; Drug Resistance, Multiple, Bacterial; Epidemiological Monitoring; Epidemiology. Vaccinations; Female; General aspects; Gram-negative bacteria; Hospitalization; Hospitals; Human infectious diseases. Experimental studies and models; Humans; Infection Control; Infection Control - standards; Infectious Disease; Infectious diseases; Intubation, Intratracheal - adverse effects; Logistic Models; Medical sciences; Multidrug-resistant Pseudomonas aeruginosa; Nosocomial infections; Prevalence; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - isolation & purification; Pseudomonas Infections - epidemiology; Pseudomonas Infections - microbiology; Risk Factors; Southern China; Asia; China; Guangzhou China; Southern China; Case-control surveillance; Multidrug-resistant Pseudomonas aeruginosa; Pseudomonadales; Nosocomial infection; Check; Case control study; Prevention; Surveillance; Multiple resistance; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Hospital
• ISSN: 0196-6553; 1527-3296
• DOI: 10.1016/j.ajic.2014.08.006

Background Multidrug-resistant Pseudomonas aeruginosa (MDRPA) is one of the most common agents among health care–associated infections. There is a lack of data on the clinical features of MDRPA from Southern China. Methods A case-control surveillance study of P aeruginosa was conducted based on surveillance from July 2008-December 2012, in 5 hospitals of Guangzhou, China. Data were analyzed by univariate analysis and multivariate logistic regression using Stata 13 (StataCorp, College Station, TX). Results Of the 348 P aeruginosa strains, the prevalence of MDRPA was 54%, and it has increased over time. Isolates of P aeruginosa showed increased resistance to most antimicrobials during this time period. Independent risk factors were tracheal intubation insertion (odds ratio [OR], 2.21; 95% confidence interval [CI], 1.16-4.23; P  = .02) and use of carbapenem (odds ratio [OR], 3.36; 95% confidence interval [CI], 1.75-6.47; P  < .01). The distribution of MDRPA infections was uneven among the 5 hospitals ( P  = .01). Being infected with MDRPA strains resulted in longer duration of hospitalization (39 vs 24 days) and higher mortality (49% vs 20%). Conclusion The infections of MDRPA were severe issues. More stringent measures should be applied for those with independent predictors of MDRPA infections because they may induce adverse clinical outcomes.