Cystodamine, a new cytotoxic fused polyaromatic alkaloid from the Mediterranean ascidian Cystodytes delle chiajei

a fused pentacyclic aromatic alkaloid - cystodamine - was isolated from a Mediterranean ascidian Cystodytes delle chiajei (Polycitoridae). The structure, determinated by extensive 2D-NMR means, is the first example of a marine product displaying a 1H- 14N coupling during 1H NMR analysis. a fused pen...

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Bibliographic Details
Published inTetrahedron letters Vol. 35; no. 38; pp. 7023 - 7026
Main Authors Bontemps, Nataly, Bonnard, Isabelle, Banaigs, Bernard, Combaut, Georges, Francisco, Christian
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.09.1994
Elsevier
Subjects
Alcaloids
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemistry
Chemistry, Organic
Fundamental and applied biological sciences. Psychology
Heterocyclic compounds, pigments
Other biological molecules
Physical Sciences
Science & Technology
AROMATIC ALKALOIDS
Antineoplastic agent
Pentacyclic compound
Alkaloid
Molecular structure
Nitrogen heterocycle
Isolation
Aromatic compound
NMR spectrum
Ketone
Biological activity
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Summary:a fused pentacyclic aromatic alkaloid - cystodamine - was isolated from a Mediterranean ascidian Cystodytes delle chiajei (Polycitoridae). The structure, determinated by extensive 2D-NMR means, is the first example of a marine product displaying a 1H- 14N coupling during 1H NMR analysis. a fused pentacyclic aromatic alkaloid -cystodamine- was isolated from a Mediterranean ascidian Cystodytes delle chiajei (Polycitoridae). The structure, determinated by extensive 2D-NMR means, is the first example of a marine product displaying a 1H 14N coupling during 1H NMR analysis.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(94)88215-0