Impact of invasive treatment strategy on health-related quality of life six months after non-ST-elevation acute coronary syndrome

• Published in: Journal of geriatric cardiology : JGC Vol. 11; no. 3; pp. 206 - 211
• Main Authors: Yang, Li-Xia, Zhou, Yu-Jie, Wang, Zhi-Jian, Li, Yue-Ping, Chai, Meng
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, N0. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, China 01.09.2014; Science Press
• Subjects: Logistic回归分析; 介入治疗; 健康状况; 冠状动脉; 急性冠脉综合征; 生活质量; 逻辑回归模型; Therapeutic strategy; Non-ST elevation acute coronary syndrome; Quality of life
• ISSN: 1671-5411
• DOI: 10.11909/j.issn.1671-5411.2014.03.003

BackgroundFew studies have compared change in the health-related quality of life （HRQL） following treatment of non-ST-elevation acute coronary syndrome （NSTE-ACS） with either percutaneous coronary intervention （PCI） or coronary artery bypass grafting （CABG）. This study is tocompare changes in HRQL six months after hospital discharge between NSTE-ACS pa-tients who underwent either PCI or CABG.Methods HRQL was assessed using the Seattle angina questionnaire at admission and six months after discharge in 1012 consecutive patients with NSTE-ACS. To assess associations of PCI and CABG with HRQL changes, logistic regression models were constructed treating changes in the score of each dimension of the Seattle angina question-naire as dependent variables.Results Although both the PCI and CABG groups experienced angina relief and other improvements at 6-month follow-up （P〈0.001）, the CABG relative to PCI group showed more significant improvements in angina frequency （P= 0.044） and quality of life （P= 0.028）. In multivariable logistic analysis, CABG also was an independent predictor for both im-provement of angina frequency （OR： 1.62, 95%CI： 1.09-4.63,P= 0.042） and quality of life （OR： 2.04, 95%CI： 1.26-6.92,P= 0.038） relative to PCI.Conclusions In patients with NSTE-ACS, both PCI and CABG provide great improvement in disease-specific health status at six months, with that of CABG being more prominent in terms of angina frequency and quality of life.