The potential role of lncRNAs in osteoporosis

• Published in: Journal of bone and mineral metabolism Vol. 39; no. 3; pp. 341 - 352
• Main Authors: He, Yinxi, Chen, Yanxia
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.05.2021; Springer Nature B.V
• Subjects: Animals; Bone (long); Bone diseases; Bone mass; Bone Remodeling - genetics; Clinical Trials as Topic; Humans; Medicine; Medicine & Public Health; Metabolic Diseases; Molecular modelling; Non-coding RNA; Nucleotides; Orthopedics; Osteoclasts - metabolism; Osteoclasts - pathology; Osteogenesis - genetics; Osteoporosis; Osteoporosis - genetics; Osteoporosis - physiopathology; Review Article; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Osteoclast function; Long non-coding RNAs (lncRNAs); Osteoporosis; Osteoblast function
• ISSN: 0914-8779; 1435-5604
• DOI: 10.1007/s00774-021-01205-6

Osteoporosis is a common bone disease characterized by low bone mass and deterioration of bone microstructure, which predisposes to higher risks of bone fragility and bone fracture. Long non-coding RNAs (lncRNAs) are a class of RNAs with a length of > 200 nucleotides without protein-coding function, which control the expression of genes and affect multiple biological processes. Accumulating evidence suggests that lncRNAs are widely involved in the molecular mechanisms of osteoporosis. This review aims to summarize the function and underlying mechanism of lncRNAs involved in the development of osteoporosis, and how it contributes to osteoblast and osteoclast function. This knowledge will shed new light on the modulation and potential treatment of osteoporosis.