A new metabolite, mannogeranylnerol, specifically produced at body temperature by Schizophyllum commune, a causative fungus of human mycosis

Schizophyllum commune is a causative fungus of human mycosis. Its metabolites produced at 27 °C were compared with those produced at 37 °C, to obtain a candidate low-molecular-weight virulence factor related to the pathogenicity of this fungus. We found that S. commune specifically produces two acyc...

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Published inJournal of antibiotics Vol. 75; no. 4; pp. 243 - 246
Main Authors Tam, Shing Yiu, Uchida, Kenichi, Enomoto, Hirofumi, Takahashi, Senji, Makimura, Koichi, Sakuda, Shohei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2022
Springer Nature
Nature Publishing Group
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Summary:Schizophyllum commune is a causative fungus of human mycosis. Its metabolites produced at 27 °C were compared with those produced at 37 °C, to obtain a candidate low-molecular-weight virulence factor related to the pathogenicity of this fungus. We found that S. commune specifically produces two acyclic terpene mannosides at 37 °C. They were identified as nerolidol β- d -mannoside ( 1 ) and geranylnerol β- d -mannoside ( 2 ) by NMR, MS, and CD analyses. Compound 2 , a new compound named mannogeranylnerol, showed weak antibiotic activity that was slightly stronger than that of compound 1 .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-022-00511-z