A new metabolite, mannogeranylnerol, specifically produced at body temperature by Schizophyllum commune, a causative fungus of human mycosis

• Published in: Journal of antibiotics Vol. 75; no. 4; pp. 243 - 246
• Main Authors: Tam, Shing Yiu, Uchida, Kenichi, Enomoto, Hirofumi, Takahashi, Senji, Makimura, Koichi, Sakuda, Shohei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Springer Nature; Nature Publishing Group
• Subjects: 631/326/193/2542; 631/326/22/1290; Antibiotics; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Body temperature; Brief Communication; Fungal infections; Fungi; Immunology; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Metabolites; Microbiology; Mycosis; Nerolidol; NMR; Nuclear magnetic resonance; Organic Chemistry; Pathogenicity; Pathogens; Pharmacology & Pharmacy; Schizophyllum commune; Science & Technology; Virulence; Virulence factors; GERANYLGERANIOL; DITERPENE
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/s41429-022-00511-z

Schizophyllum commune is a causative fungus of human mycosis. Its metabolites produced at 27 °C were compared with those produced at 37 °C, to obtain a candidate low-molecular-weight virulence factor related to the pathogenicity of this fungus. We found that S. commune specifically produces two acyclic terpene mannosides at 37 °C. They were identified as nerolidol β- d -mannoside ( 1 ) and geranylnerol β- d -mannoside ( 2 ) by NMR, MS, and CD analyses. Compound 2 , a new compound named mannogeranylnerol, showed weak antibiotic activity that was slightly stronger than that of compound 1 .