Nedaplatin-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report and review of the literature

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is relatively common in several cancers, such as small cell lung cancer. However, nedaplatin-induced SIADH is rare. We describe a case of SIADH mediated by nedaplatin. A 54-year-old female with nasopharyngeal carcinoma was treated w...

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Published inWorld journal of clinical cases Vol. 9; no. 23; pp. 6810 - 6815
Main Authors Tian, Lei, He, Li-Ya, Zhang, Hong-Zhen
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 16.08.2021
Subjects
Case Report
Nedaplatin
Case report
Hyponatremia
Fluid restriction
Syndrome of inappropriate secretion of antidiuretic hormone
Sodium supplementation
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Summary:Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is relatively common in several cancers, such as small cell lung cancer. However, nedaplatin-induced SIADH is rare. We describe a case of SIADH mediated by nedaplatin. A 54-year-old female with nasopharyngeal carcinoma was treated with nedaplatin and developed severe hyponatremia due to SIADH. The side effects were successfully treated by fluid restriction and sodium supplementation. This case report highlights the importance of cautiously treating life-threatening hyponatremia in patients treated with nedaplatin.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
Author contributions: Tian L reviewed the literature and wrote the manuscript; He LY was the patient’s doctor in charge; Zhang HZ contributed to the literature review; and all authors have read and approved the final manuscript.
Corresponding author: Hong-Zhen Zhang, PhD, Doctor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, China. 1256596529@qq.com
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v9.i23.6810