The Effect of Iron Therapy in Paroxysmal Nocturnal Hemoglobinuria

Two patients with paroxysmal nocturnal hemoglobinuria who were iron deficient were treated with parenteral iron compounds. In both instances, a marked increase in hemoglobinuria followed, beginning 4 days after the first administration of the iron compound. The rise in hemolysis paralleled the rise...

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Bibliographic Details
Published inBlood Vol. 36; no. 5; pp. 559 - 565
Main Authors Rosse, Wendell F., Gutterman, Lorence A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.1970
Subjects
Blood Cell Count
Blood Transfusion
Complement System Proteins
Erythropoiesis - drug effects
Fluoxymesterone - therapeutic use
Hematuria
Hemoglobinometry
Hemoglobinuria - etiology
Hemoglobinuria, Paroxysmal - drug therapy
Hemolysis - drug effects
Humans
Iron - administration & dosage
Iron - adverse effects
Iron - blood
Iron - therapeutic use
Male
Middle Aged
Reticulocytes
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Summary:Two patients with paroxysmal nocturnal hemoglobinuria who were iron deficient were treated with parenteral iron compounds. In both instances, a marked increase in hemoglobinuria followed, beginning 4 days after the first administration of the iron compound. The rise in hemolysis paralleled the rise in reticulocyte count. When erythropoiesis was suppressed with transfusion, the administration of iron did not bring about an increase in hemolysis. This indicates that the effect of iron in bringing about hemolysis in patients with paroxysmal nocturnal hemoglobinuria is due to an increase in erythropoiesis, resulting in the production of excessive numbers of complement-sensitive cells.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V36.5.559.559