Target Organ Pathology in Iron-Deficient Suckling Rats

Pathological changes in 18-day-old rat pups from iron-deficient dams (5 ppm dietary iron) included severe fatty degeneration of the liver with focal hepatocellular necrosis plus complete depression of hemopoiesis in this organ. Similar fatty degeneration occurred in the cortical tubular epithelial c...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 110; no. 8; pp. 1648 - 1654
Main Authors Rothenbacher, Hans, Sherman, Adria Rothman
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1980
Subjects
anemia
Anemia - immunology
Anemia - physiopathology
animal diseases
animal health
Animals
Animals, Newborn
Female
histopathology
Iron - deficiency
Kidney - pathology
Liver - pathology
Myocardium - pathology
noninfectious diseases
Organ Size
Pregnancy
Rats
Spleen - immunology
Spleen - pathology
Thymus Gland - immunology
Thymus Gland - pathology
histopathology
iron-deficiency
anemia
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Summary:Pathological changes in 18-day-old rat pups from iron-deficient dams (5 ppm dietary iron) included severe fatty degeneration of the liver with focal hepatocellular necrosis plus complete depression of hemopoiesis in this organ. Similar fatty degeneration occurred in the cortical tubular epithelial cells of the kidneys of deficient rats. Lesions in spleens and thymuses of the iron-deficient rat pups indicate depression of hemopoiesis and lymphopoiesis of both thymus-dependent lymphocyte (T-cell) and bursa-equivalent lymphocyte (B-cell) areas. From the qualitative and quantitative evaluation of thymus and spleen it may be concluded that the iron-deficient young rats are immunologically retarded and/or are permanently less competent than the controls.
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ISSN:0022-3166
1541-6100
DOI:10.1093/jn/110.8.1648