Design of an in-dwelling cannula for convection-enhanced delivery

• Published in: Journal of neuroscience methods Vol. 196; no. 1; pp. 118 - 123
• Main Authors: Rosenbluth, Kathryn H., Luz, Matthias, Mohr, Erich, Mittermeyer, Stephan, Bringas, John, Bankiewicz, Krystof S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2011
• Subjects: Animals; Brain - anatomy & histology; Cannula; Catheterization - instrumentation; Contrast Media - administration & dosage; Convection; Convection-enhanced delivery; Drug Delivery Systems - instrumentation; Equipment Design; Follow-Up Studies; Gadolinium; Heterocyclic Compounds - administration & dosage; Infusion; Macaca mulatta; Magnetic Resonance Imaging; MRI; Neuro-oncology; Neurodegeneration; Non-human primate; Organometallic Compounds - administration & dosage; Primates; Reproducibility of Results; Infusion; Convection-enhanced delivery; Cannula; MRI; Neurodegeneration; Non-human primate; Neuro-oncology
• ISSN: 0165-0270; 1872-678X
• DOI: 10.1016/j.jneumeth.2010.12.022

▶ A novel cannula for convection-enhanced delivery (CED) trials is presented. ▶ The cannula is in-dwelling, MRI-compatible and reflux-resistant. ▶ The cannula is designed for use in upcoming trials in neuro-oncology and neurodegeneration. ▶ The cannula performance is validated in non-human primate infusions. Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.