Echinococcus granulosus: Ovicidal activity of praziquantel and bunamidine hydrochloride

Eggs of Echinococcus granulosus either released from or contained within the proglottids were treated with praziquantel and bunamidine hydrochloride at 37 C for 1 hr and then administered orally to mice and gerbils to test their infectivity. Praziquantel did not possess absolute ovicidal activity ag...

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Bibliographic Details
Published inExperimental parasitology Vol. 47; no. 2; pp. 131 - 133
Main Authors Thakur, A.S, Prezioso, U, Marchevsky, N
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1979
Subjects
Amidines - pharmacology
animal diseases
animal health
Animals
Anticestodal Agents - pharmacology
Bunamidine hydrochloride
Cestode
control
Echinococcus - drug effects
Echinococcus - growth & development
Echinococcus granulosus
Female
Gerbil
Gerbillinae
Hydatid disease
Mouse
Ovicide
Ovum - drug effects
Praziquantel
Rats
Hydatid disease
Mouse
Praziquantel
Bunamidine hydrochloride
Ovicide
Cestode
control
Gerbil
Echinococcus granulosus
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Summary:Eggs of Echinococcus granulosus either released from or contained within the proglottids were treated with praziquantel and bunamidine hydrochloride at 37 C for 1 hr and then administered orally to mice and gerbils to test their infectivity. Praziquantel did not possess absolute ovicidal activity against E. granulosus eggs either within or outside the proglottids and bunamidine hydrochloride did not kill them within the proglottids. These findings bear on the use of praziquantel in control programs.
Bibliography:L72
7914638
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-4894
1090-2449
DOI:10.1016/0014-4894(79)90066-3