Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029
Two new compounds classified as one new lumazine peptide, penilumamide K ( 1 ) and one new sesquiterpene ( 2 ), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds ( 3 − 13 ). The structures of 1 − 13 including absolute configurations were...
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| Published in | Journal of antibiotics Vol. 74; no. 2; pp. 156 - 159 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.02.2021
Springer Nature Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Two new compounds classified as one new lumazine peptide, penilumamide K (
1
) and one new sesquiterpene (
2
), were obtained from the deep-sea derived fungus
Aspergillus
sp. SCSIO 41029, together with eleven known compounds (
3
−
13
). The structures of
1
−
13
including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound
1
represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds
1
,
3
,
4
,
5
,
7
and
10
had significant potency against
α
-glucosidase with IC
50
values ranging from 18.61 to 109.06 μΜ. In addition, compounds
4
and
9
showed strong antibacterial activity against
Staphylococcus aureus
with MIC values of 0.78 and 6.25 μg ml
−1
, respectively. |
|---|---|
| AbstractList | Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against alpha-glucosidase with IC50 values ranging from 18.61 to 109.06 mu M. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 mu g ml(-1), respectively. Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3−13). The structures of 1−13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml−1, respectively. Two new compounds classified as one new lumazine peptide, penilumamide K ( 1 ) and one new sesquiterpene ( 2 ), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds ( 3 − 13 ). The structures of 1 − 13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1 , 3 , 4 , 5 , 7 and 10 had significant potency against α -glucosidase with IC 50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml −1 , respectively. Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml , respectively. Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml-1, respectively.Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml-1, respectively. |
| Author | Zhou, Xuefeng Chen, Weihao Chen, Chunmei Lan, Sujuan Wang, Junfeng Liu, Yonghong Long, Jieyi Lin, Xiuping Liao, Shengrong Yang, Bin |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33106626$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1021_acs_jafc_3c05955 crossref_primary_10_3389_fmicb_2024_1464135 crossref_primary_10_1039_D3CB00088E crossref_primary_10_1002_cbdv_202200208 crossref_primary_10_3390_md22070321 crossref_primary_10_1007_s13659_025_00501_2 crossref_primary_10_1039_D2NP00083K crossref_primary_10_2174_1872208316666220512122439 crossref_primary_10_1039_D4OB00586D crossref_primary_10_1002_cjoc_202100226 |
| Cites_doi | 10.1039/C9NP00069K 10.1039/c0np00061b 10.3390/md9081368 10.1039/C3NP70118B 10.1248/cpb.58.1221 10.1016/j.bmcl.2013.01.051 10.1248/cpb.31.1528 10.1248/cpb.48.559 10.1080/14786419.2015.1101107 10.1186/s13765-019-0451-3 10.1016/j.tetlet.2006.06.086 10.1021/np50051a030 10.1016/j.bioorg.2020.103646 10.1248/cpb.58.1545 10.1016/j.fitote.2018.08.021 10.1016/j.phytol.2019.11.009 10.1021/np50080a020 10.1039/c3np70118b 10.1039/c9np00069k |
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| Copyright | The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2020 The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2020. |
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| DOI | 10.1038/s41429-020-00378-y |
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| Keywords | TERREUS ENDOPHYTIC ASPERGILLUS BUTYROLACTONES |
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| PublicationTitle | Journal of antibiotics |
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BIOSYNTHESIS OF BUTYROLACTONE DERIVATIVES ISOLATED FROM STRAINS-IFO-8835 AND STRAIN-IFO-4100 publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN |
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| Snippet | Two new compounds classified as one new lumazine peptide, penilumamide K (
1
) and one new sesquiterpene (
2
), were obtained from the deep-sea derived fungus... Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus... |
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| SubjectTerms | 631/154/309 631/326/193 Antibiotics Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Biotechnology & Applied Microbiology Brief Communication Carbon Deep sea Fungi Immunology Laboratories Life Sciences Life Sciences & Biomedicine Medicinal Chemistry Metabolites Microbiology Organic Chemistry Peptides Pharmacology & Pharmacy Science & Technology Secondary metabolites |
| Title | Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029 |
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