Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029

• Published in: Journal of antibiotics Vol. 74; no. 2; pp. 156 - 159
• Main Authors: Chen, Weihao, Chen, Chunmei, Long, Jieyi, Lan, Sujuan, Lin, Xiuping, Liao, Shengrong, Yang, Bin, Zhou, Xuefeng, Wang, Junfeng, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2021; Springer Nature; Nature Publishing Group
• Subjects: 631/154/309; 631/326/193; Antibiotics; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Brief Communication; Carbon; Deep sea; Fungi; Immunology; Laboratories; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Metabolites; Microbiology; Organic Chemistry; Peptides; Pharmacology & Pharmacy; Science & Technology; Secondary metabolites; TERREUS; ENDOPHYTIC ASPERGILLUS; BUTYROLACTONES
• ISSN: 0021-8820; 1881-1469; 1881-1469
• DOI: 10.1038/s41429-020-00378-y

Two new compounds classified as one new lumazine peptide, penilumamide K ( 1 ) and one new sesquiterpene ( 2 ), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds ( 3 − 13 ). The structures of 1 − 13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1 , 3 , 4 , 5 , 7 and 10 had significant potency against α -glucosidase with IC 50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml −1 , respectively.