Preparation and properties of copoly(n-hydroxyalkyl- d,l-glutamine) membranes

• Published in: European polymer journal Vol. 31; no. 5; pp. 453 - 458
• Main Authors: Hayashi, Toshio, Nakanishi, Eiji, Iizuka, Yasuko, Oya, Masanao, Iwatsuki, Makoto
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.05.1995; Elsevier
• Subjects: Applied sciences; Exact sciences and technology; Exchange resins and membranes; Forms of application and semi-finished materials; Polymer industry, paints, wood; Technology of polymers; Enzyme; Biodegradability; Cysteine endopeptidases; Aminoacid copolymer; Mechanical properties; Papain; Gamma benzyl glutamate copolymer; Experimental study; Crosslinked copolymer; Random copolymer; Alcohol copolymer; Chemical modification; Steam permeability; Aminolysis; Preparation; Enzymatic digestion; Hydrolases; Membrane; Property structure relationship; Proteinases; Glutamic acid derivative copolymer
• ISSN: 0014-3057; 1873-1945
• DOI: 10.1016/0014-3057(94)00189-8

Random copolypeptide (PHADLG) membranes consisting of N-hydroxyalkyl- d-glutamine (HADG) and N-hydroxylalkyl- l-glutamine (HALG) covering the whole range of d,l-copolymer composition were prepared by carrying out aminolysis reactions with 3-amino-1-propanol (P) or 5-amino-1-pentanol (Pe), together with a crosslinking reaction with 1,8-octamethylenediamine (OMDA) on membranes of the starting random copolymers (PBDLG) consisting of γ-benzyl- d-glutamate and γ-benzyl- l-glutamate. The relationships between their bulk structure and membrane properties were investigated, such as the swelling ratio in water, tensile properties, water vapour permeability, and enzymatic degradation behaviour of the membranes in a pseudo-extracellular fluid (PECF), as a function of d,l-copolymer composition. The tensile properties of d,l-copolymer membranes were highly dependent on the swelling ratio of PECF. Biodegradation of these membranes in vitro by papain indicated that degradation was a bulk rather than a surface phenomenon, and that the rate of degradation of membranes was also highly dependent on the hydrophobicity of side chains, d,l-copolymer composition as well as on the swelling ratios of the d,l-copolymer samples.