Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature
Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type o...
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| Published in | World journal of clinical cases Vol. 7; no. 23; pp. 4063 - 4074 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Baishideng Publishing Group Inc
06.12.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2307-8960 2307-8960 |
| DOI | 10.12998/wjcc.v7.i23.4063 |
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| Summary: | Micronodular thymic tumors with lymphoid stroma include micronodular thymoma with lymphoid stroma (MNT) and micronodular thymic carcinoma with lymphoid hyperplasia (MNC), whose micromorphological features are lymphoid stromal hyperplasia and nodular arrangement of tumor epithelial cells. This type of tumor is rare; therefore, the corresponding clinical guidelines, histopathological diagnostic criteria, prognostic factors, and therapeutic regimens have not been established.
This study covers a novel presentation of MNC in a patient and summarizes the clinicopathological characteristics of this type of tumor by using pooled-analysis methods. Morphologically, this tumor type is a series of benign to malignant pedigrees. We establish the following criteria for the classification of micronodular thymic tumors with lymphoid stroma: (1) Tumor cells with moderate-to-severe dysplasia; (2) Tumor cell mitotic figures > 2/10 high-power fields; (3) Appearance of neoplastic necrosis; (4) No terminal deoxynucleotidyl transferase-positive immature T lymphocytes within the tumor; (5) Tumor cells with a Ki-67 index ≥ 10%; and (6) Tumor cells express CD5. Cases that fall into the borders of two categories in terms of morphology are attributed to atypical MNT. It is proposed that the diagnosis of MNT should be established on the diagnostic criteria mentioned above.
Our diagnostic algorithm can effectively distinguish malignant tumors from benign tumors and provides a potent basis for predicting a prognosis, which offers a practical reference for oncologists and pathologists. |
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| Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Author contributions: Zhong DR was responsible for the overall design of the paper and reviewed the contents of the paper; Wang B performed the histological examination of the case, was responsible for retrieving, reading, and collating the references, and was also a major contributor in writing the manuscript; Li K was responsible for retrieving, reading, and screening of the literature; Song QK was responsible for all statistical work; Wang XH performed the histological examination of the case and took all the pictures; Yang L and Zhang HL were responsible for all histological staining, immunohistochemical staining, and molecular detection. All authors read and approved the final manuscript. Corresponding author: Ding-Rong Zhong, MD, Director, Professor, Department of Pathology, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Beijing 100029, China. txzzzryy@163.com Telephone: +86-10-69159370 |
| ISSN: | 2307-8960 2307-8960 |
| DOI: | 10.12998/wjcc.v7.i23.4063 |