Notch signaling: the demise of elegant simplicity

Notch signaling can be viewed as an elegantly simple pathway that begins when the Notch receptor binds ligand, and ends when the Notch intracellular domain enters the nucleus and activates transcription. However, it is becoming increasingly clear that this core pathway is subject to a wide array of...

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Bibliographic Details
Published inCurrent opinion in genetics & development Vol. 14; no. 5; pp. 506 - 512
Main Author Kadesch, Tom
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2004
Subjects
Animals
Calcium - metabolism
Humans
Ligands
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - metabolism
Receptors, Notch
Signal Transduction
Substrate Specificity
MeCP2
TGF
BMP
MINT
HES
NICD
NIC
NRARP
SMRT
HRT
CSL
N IC
Online AccessGet full text
ISSN0959-437X
1879-0380
DOI10.1016/j.gde.2004.07.007

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Summary:Notch signaling can be viewed as an elegantly simple pathway that begins when the Notch receptor binds ligand, and ends when the Notch intracellular domain enters the nucleus and activates transcription. However, it is becoming increasingly clear that this core pathway is subject to a wide array of regulatory influences, from those that affect ligand–receptor interactions to those that govern the choice of Notch target genes. Even Notch ligands are now being scrutinized with respect to the possibility that they, too, function in the nucleus. A complete understanding of Notch signaling therefore requires us to look well beyond the core pathway.
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ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2004.07.007