Acute and Subacute toxicity study of Olaquindox by feeding to common carp (Cyprinus carpio L.)

• Published in: Ecotoxicology and environmental safety Vol. 161; pp. 342 - 349
• Main Authors: Yang, Qian, He, Jie, He, Sheng-yu, Wang, Kai-yu, Geng, Yi, Chen, De-fang, Huang, Xiao-li, Ou-yang, Ping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.10.2018
• Subjects: Accumulation; Cyprinus carpio L; Histopathology; Olaquindox; Toxicity; Cyprinus carpio L; Histopathology; Toxicity; Olaquindox; Accumulation
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2018.05.079

Olaquindox, is a growth-promoting feed additive for food-producing animals. As the banned medicinal feed additive, olaquindox in animal feed and water must be concerned as an important hazard index. To improve studies of the toxicity of olaquindox, we provide a toxicological effects of olaquindox on a common freshwater fish, Cyprinus carpio L. The results of acute toxicity tests showed that the 7d-LD50 of olaquindox administered by feeding for common carp was determined to be 3746.3 mg/kg. We also found that the accumulation coefficient of olaquindox in carp was 1.45–1.9. Based on the studied hematological and blood biochemical parameters (RBCs count, hemoglobin content, ALT, AST and SOD activity), we found that olaquindox induced significant alterations in all studied parameters. Regarding bioaccumulation, the results showed that olaquindox had more efficiency to internalize fish tissues (liver, kidneys and muscle). The histopathological investigation of tissues from poisoning fish revealed various alterations that varied between adaptation responses and permanent tissue damage. Our results indicate that olaquindox are toxic to common carp and have obvious accumulation, and all the data from acute and subacute toxicity experiments in common carp may provide a useful tool for assessing the toxicity of olaquindox to aquatic organisms. •7d-LD50 of olaquindox administered by feeding for carp was 3746.3 mg/kg.•The accumulation coefficient of olaquindox in carp was 1.45–1.9.•Significant alterations showed in hematological/blood biochemical parameters.•Histopathological investigation found permanent tissue damage.•Olaquindox had more efficiency to internalize in active metabolic organs.